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These abnormalities not only exacerbate glomerular and tubular injury through lipotoxicity and oxidative stress but also give rise to a range of circulating metabolites with potential utility as biomarkers for disease risk stratification [3]

The authors reported that cagrilintide adopts an amylin-like pose while inducing receptor-specific conformational dynamics, offering a structural framework for interpreting its pharmacology.

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Nielsen et al., 2013) as well as solid tumors (Tsimberidou et al., 2009